高考问答元旦节高速路是否免费:在线等。。。药学英语翻译
来源：百度文库 编辑：高考问答 时间：2024/04/29 04:46:51
Peak blood levels are reached within one hour after oral administration of cetirizine.The plasma half-life is approximately 10 hours in adults, 6 hours in children aged 6 to 12 years and 5 hours in children aged 2 to 6 years. These data are consistent with the urinary excretion half-life of the drug.The cumulative urinary excretion represents about two thirds of the dose given in both adults and children. Consequently, the apparent plasma clearance in children is higher than that measured in adults.
Absorption is very consistent from one subject to the next.
Plasma levels are linearly reated to the dose given.
Cetirizine is strongly bound to plasma proteins.
Absorption is very consistent from one subject to the next.
Plasma levels are linearly reated to the dose given.
Cetirizine is strongly bound to plasma proteins.
口服西替利嗪1小时内达到其血浆浓度峰值，半衰期为10小时（成人）、6小时（6-12岁儿童）、5小时（2-6岁儿童），与尿检存量一致，
成分的累积尿排量为2/3，因此，儿童的肾清除率与比成人要高。
血浆浓度与剂量线性相关。
西替利嗪与血浆蛋白的结合度非常高（90%以上）。