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来源:百度文库 编辑:高考问答 时间:2024/05/10 07:44:49
The Impact of Structural Genomics:Expectations and Outcomes
John-Marc Chandonia and Steven E. Brenner*
Structural genomics (SG) projects aim to expand our structural knowledge of biologicalmacromolecules while lowering the average costs of structure determination. We quantitativelyanalyzed the novelty, cost, and impact of structures solved by SG centers, and we contrast theseresults with traditional structural biology. The first structure identified in a protein family enablesinference of the fold and of ancient relationships to other proteins; in the year ending 31 January2005, about half of such structures were solved at a SG center rather than in atraditionallaboratory. Furthermore, the cost of solving a structure at the most efficient SG center in the United
States has dropped to one-quarter of the estimated cost of solving a structure by traditional
methods. However, the efficiency of the top structural biology laboratories—even though they work
on very challenging structures—is comparable to that of SG centers; moreover, traditional
structural biology papers are cited significantly more often, suggesting greater current impact.
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